Sanitary Tube-in-Tube Heat Exchangers in Pharmaceuticals

Sanitary tube-in-tube heat exchangers consist of two tubes, an inner and an outer coiled together. This unique, compact design prevents thermal fatigue, increases efficiency and reduces the overall size. It is ideal for high temperature, high pressure and low flow applications.

These sanitary models are designed to meet the high quality requirements and hygienic standards of the pharmaceutical industry. All product contact surfaces have a maximum surface finish of 20in (0.5m) Ra, and can be improved to 15in (0.5m) Ra or better with optional electropolishing. Our unique design ensures there is no risk of cross-contamination between the product and working fluids.

Performance Features:

  • Heat transfer rates to 100,000 BTU/hr (29 kW)

  • Liquid flows to 10 GPM (38 LPM)

  • Pressures up to 4,500 psi (310 bar)

Sanitary Features:

  • Available with or without electropolish

  • No risk of cross-contamination between fluids

  • Sanitary fittings ASME BPE

  • Material & process certifications included

  • Fully drainable on product side

  • Clean-in-place (CIP)

  • No dead spots or crevices

  • ASME BPE Compliant

Design Features:

  • 316L SS, Hastelloy®, Inconel®, Titanium and other alloys

  • NPT, tube stubs, or custom fittings

  • Thick walled seamless tube

  • Integrated threaded holes for mounting

  • Highly resistant to thermal stress

  • All welded construction

  • Maintenance free


POINT-OF-USE (POU) SAMPLING SYSTEM

Exergy Point-Of-Use systems dispense instant, temperature controlled WFI or PW, and are designed to meet the high quality requirements and hygienic standards of the pharmaceutical industry. When not in use, a continuous flow of hot water (from the main loop) maintains sanitization. Exergy offers standard models using our compact, high performance heat exchangers for the most demanding conditions. Many features and options can be customized.

Benefits:

  • Instant cold or hot WFI or PW availability at POU

  • Continuous flow of hot water keeps it sanitized at all times

  • Automated or manual operation

  • PLC with touch screen HMI with many operating modes

  • Fully drainable on product side, with no dead legs

  • Easy to install, operate and maintain

  • CIP and SIP capable

Design Features:

  • Enclosed locking cabinet

  • Sanitary double tube sheet heat exchanger eliminates risk of cross contamination between product and working fluid

  • All product contact surfaces are passivated, less than 20 Ra and electropolish available

  • 316L stainless steel construction

  • Full quality documentation provided


Exergy sanitary shell & tube heat exchangers are designed to meet the high quality requirements and hygienic standards of the pharmaceutical industry. All product contact surfaces have a maximum surface finish of 20in (0.5m) Ra, and can be improved to 15in (0.4m) Ra or better with optional electropolishing. Available with single tubesheet or double tubesheet to eliminate risk of cross-contamination between the product and working fluids.

Performance Features:

  • Heat transfer rates to 3,500,000 BTU/hr (1025 kW)

  • Liquid flows to 160 GPM (605 LPM)

  • Pressures up to 1,500 psi (104 bar)

Design Features:

  • 316L SS, Hastelloy®, Inconel®, Titanium and other alloys

  • Nickel brazed (no welds)

  • Fully drainable on tube side

  • ASME BPE sanitary fittings

  • ASME BPE compliant

  • Clean-in-place (CIP)

  • Available with or without electropolish

  • Material & process certifications included

Case Histories

Application: FERMENTATION The customer requires a heat exchanger that can maintain temperature at 11C during fermentation; heating up from ambient temperature and recirculation through a ultrafiltration skid. The batch size is 1000L of water and cooling liquid is 2C glycol or 7C chilled water.

Solution • Sanitary Shell & Tube Heat Exchanger • Model 02125, 95 Series • All components 316L Stainless Steel

Features & Benefits • Heat Transfer Area: 9.54 to 32.50 ft² • Double Tube Sheet • Shell Diameter : 4.00”

Application: HEATING LIQUIDS The customer is heating organic solvents from 20C to 70C. The working fluid is silicone oil, at 100C. The allowable pressure for the cold side is 60 bar and hot side is 5 bar.

Solution • Sanitary Shell & Tube Heat Exchanger • Model 02626, 73 Series • All components 316L Stainless Steel

Features & Benefits • Heat Transfer Area: 16.16 ft² • Double Tube Sheet • Shell Diameter: 3.00” • Tube Length: 26”

Application : POINT-OF-USE COOLER FOR WASH STATIONS Our customer is building a plant and needed POU coolers at multiple wash stations to cool PW from 75C to 25C at 5 gpm, using 5 deg C chilled water. They required customized units to meet their specific requirements while meeting critical delivery dates.

Solution • Seven (7) Customized POU Coolers • Delivered in 10 weeks

Features & Benefits • Valve in header allowed bypass flow to be adjusted for various conditions • Customization included: – PID control valve for chilled water – Sloped top of cabinet – CHW Inlet/Outlet ports relocated to side – Customer specified valves – Low point drain and air vents

Therefore Heat Transfer Specialists if you have to deal with special high value fluids (organic pharmaceuticals or Water For Injection WFI) consider special Miniature Heat Exchangers like Exergy’s extensive engineering expertise, unique designs and manufacturing techniques providing the most compact heat exchangers.

Shell and Tube heat exchangers, Tube-in-Tube heat exchangers, and Point-of-Use (POU) sampling systems constructed of 316L SS, Hastelloy, Inconel, Titanium and other alloys.